Home »Botox® Library » Nerve Locations and Botox® Injections

Nerve Locations and Botox® Injections

Mastery of facial anatomy, especially the nerve network beneath the skin, is critical for anyone delivering Botox® (onabotulinumtoxinA) injections. These treatments, widely celebrated for reducing wrinkles and rejuvenating appearance, demand anatomical precision to prevent unwanted complications. Knowing the nerve locations to avoid during Botox® injections minimizes side effects while maximizing outcomes, ensuring both safety and patient satisfaction.

Whether you’re an aesthetic professional aiming to enhance your skills or a patient seeking well-informed choices, understanding nerve anatomy is indispensable for successful Botox® treatments. In this article, we explore why nerve locations matter, highlight key “danger zones,” and offer actionable strategies to improve safety.

Key Takeaways Nerve Locations and Botox®

Avoidance of specific nerves is vital to prevent undesirable side effects such as muscle weakness, facial asymmetry, or sensory changes during Botox® injections.
Major nerve branches to be mindful of include the facial nerve (particularly its temporal, zygomatic, and buccal branches), the supraorbital and supratrochlear nerves, and the mental nerve.
Detailed anatomical knowledge, visualization of landmarks, and conservative injection techniques help practitioners safely navigate areas close to vulnerable nerves.
Ongoing anatomical education and hands-on training are essential for all injectors to consistently deliver safe and effective Botox® procedures.

Why Nerve Location Awareness Is Critical for Botox®

Botox® works by temporarily relaxing muscles at or near the injection site. While the treatment is highly effective and has a strong track record of safety, poor understanding of nerve anatomy can lead to complications such as unintended muscle paralysis, numbness, or long-lasting asymmetry. These outcomes happen most often when injectors inadvertently place Botox® too close to nerve branches that control muscle movement or sensation.

Knowing which nerves are in proximity to common injection sites—and how to avoid them—empowers clinicians to minimize risk while maximizing results for patients seeking aesthetic refreshment.

Learn to Start a Profitable Aesthetics Practice in Just 4-Days!

December 5-8
in sunny Scottsdale, AZ

Make More. Work Less.

Start your transitioning to aesthetic medicine and learn everything you need to grow a profitable aesthetics practice in just 4-days!

December 5-8
Scottsdale, AZ

Only $4,195*

(Reg. $7,500. Save $3,605!)

Earn 33.5 CMEs

*Members preferred price for 4-day accelerated program. Save $3,605! Membership is only $295/yr and can be added during registration. Add a friend or team member and save $1,000 more on their 4-day registration!

Nerves and Botox® Injections

1. Facial Nerve Branches

The facial nerve (cranial nerve VII) branches into five main divisions, some of which run close to common cosmetic injection sites:

Temporal branch
- Location: Runs superiorly and laterally over the zygomatic arch toward the forehead and outer eyebrow.
- Risk: Injury can cause brow or eyelid droop (temporal branch palsy).
- Strategy: Avoid deep or lateral injections near the temporal crest; maintain injections superficial and medially directed when treating the lateral forehead.
Zygomatic and buccal branches
- Location: These pass across the cheekbone under the orbicularis oculi and zygomaticus muscles.
- Risk: Unintended diffusion can weaken the muscles controlling cheek and upper lip movement, causing asymmetry.
- Strategy: Stay superficial and lateral to bone landmarks; avoid unnecessary deep injections in the cheek region.

2. Supraorbital and Supratrochlear Nerves

These sensory nerves emerge from the orbit supplying sensation to the forehead and scalp, passing through the glabella and brow region—common Botox® injection zones.

Supraorbital nerve: Emerges through the supraorbital notch/foramen, roughly in line with the pupil.
Supratrochlear nerve: Emerges medial to the supraorbital nerve, nearer the midline of the brow.
Risk: Injection directly into or near these nerves can cause pain, numbness, or even nerve injury.
Strategy: Use fine needles, aspirate prior to injection, and place Botox® a few millimeters above the orbital rim, laterally from the supratrochlear region.

3. Mental Nerve

This nerve exits the mental foramen on each side of the jaw, supplying sensation to the lower lip and chin.

Location: Typically found below the second premolar, near the midline of the mandible.
Risk: Injecting directly into this area can cause numbness to the lower lip and uncomfortable sensations.
Strategy: Palpate and mark the location before injecting in perioral or mentalis muscle treatments; stay superficial and lateral.

Additional Safety Considerations

Infraorbital nerve
- Location: Emerges from the infraorbital foramen, under the eye, in line with the mid-pupil.
- Risk: Though less commonly encountered with Botox® (more so with fillers), avoid unnecessary deep injections in the tear trough or cheek area.
Marginal mandibular branch
- Location: Runs under the lower jawline, supplying muscles at the mouth corner.
- Risk: Deep injections in the lower face may cause lower lip weakness and asymmetry.
- Strategy: Use superficial injections, and avoid sites directly over the mandibular border.

General Guidelines for Safe Botox® Injections Around Nerves

Map out anatomical landmarks before every procedure.
Stay superficial when in doubt—most target muscles for Botox® are close to the skin’s surface.
Use conservative dosing and gradual enhancements rather than high-volume single treatments.
Seek advanced, hands-on training that emphasizes anatomy and live demonstration.
Pay attention to patient feedback about sensations during and after injection.

The Fastest Way to Get Certified in Botox® & Aesthetic Medicine

On-Demand Training with the IAPAM Learning Lab

Sign up today and expand your knowledge & skills in Botox®, Fillers, Lasers,
Chemical Peels, Microdermabrasion and PRP for Aesthetics!

Patient Perspective: What to Ask Your Provider

Patients should feel comfortable asking about their injector’s anatomical training, approach to nerve safety, and strategies for avoiding complications. A reputable clinic will welcome these questions and explain their safety protocols, increasing patient confidence and satisfaction.

Conclusion

Understanding nerve locations is fundamental for safe, predictable, and satisfying Botox® treatments. By recognizing high-risk zones and prioritizing anatomical precision, clinicians can prevent complications like numbness, asymmetry, and unwanted muscle paralysis. For both clinics and consumers, investing in anatomical education and trusting only knowledgeable providers like the IAPAM is the key to optimizing aesthetic outcomes with Botox®.

Disclaimer: The information provided here is for general knowledge only and should not be considered medical advice. For any questions or concerns about your health or medications, please consult your physician or healthcare provider. They are best equipped to provide guidance specific to your medical needs.

Get hands-on Botox® training in sunny Scottsdale, Arizona! The next Aesthetic Medicine Symposium runs September 5-8.

Nerve Locations and Botox® Injections

Key Takeaways Nerve Locations and Botox®