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GLP-1 Prescriber Library

Clinical reference guides for the physicians, nurse practitioners, physician assistants and other licensed providers who prescribe GLP-1 medications for weight management. Dosing and titration, patient selection, side-effect management, compounding rules, billing and the practice side — written for the person writing the prescription.

Last updated: September 2026

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Clinical Guides for GLP-1 Prescribers

Deep-dive guides on every aspect of prescribing GLP-1 medications for chronic weight management.

Foundations & Patient Selection

GLP-1 Mechanism of Action Explained

Receptor targets, the brain pathways that reduce appetite, slowed gastric emptying and glucose-dependent insulin release — the pharmacology behind everything else.

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Contraindications & Patient Selection

The two absolute rules, the relative cautions, a pre-prescribing screen you can run in the room, and the special populations that need a second look.

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Tirzepatide vs. Semaglutide

The SURMOUNT-5 head-to-head data, mechanism, dosing, tolerability and cost — plus how to choose between the two agents for the patient in front of you.

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Dosing & Titration

Semaglutide Dosing & Titration

The 16-week Wegovy® titration, the 7.2 mg maximum approved in 2026, Ozempic® limits and the missed-dose rules that differ by product.

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Tirzepatide Titration & Dosing

The 2.5 to 15 mg dose ladder, the four-week rule, choosing among three maintenance doses, and the four-day missed-dose window.

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Oral Semaglutide

The 25 mg oral option for weight management: the administration rules that govern absorption, monthly titration, and how efficacy compares with injection.

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Microdosing GLP-1s

What the dose-response data actually show, why compounded microdose product sits outside the rules, and how to answer patients asking for it.

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Retatrutide: Dosing & Trial Status

The investigational triple agonist: the phase 3 TRIUMPH ladder and results, the dysesthesia signal, and why there is no lawful supply to prescribe or compound.

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Side Effects & Ongoing Management

Managing GI Side Effects

Labeled nausea rates, the counseling that actually works, titration adjustments, and the red flags that mean stop rather than push through.

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Plateaus & Non-Responders

Separating an expected stall from true non-response, confirming adherence, and what to do at the week-12 decision point.

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Preventing Muscle Loss

How much lean mass patients actually lose, protein targets, and prescribing resistance training as part of the therapy rather than an afterthought.

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Pancreatitis & Thyroid Risk

What the thyroid boxed warning and the pancreatitis signal actually mean, how to screen for MTC and MEN2, and how to counsel without alarming.

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GLP-1s & Anesthesia

Current multisociety guidance says most patients can continue before surgery. Risk tiers, the liquid-diet approach, and what to tell the surgical team.

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Sourcing & Regulatory

Compounded Semaglutide in 2026

The shortage is resolved, 503B bulk compounding is out, and an FDA rule would close the remaining door. Where prescribers stand today.

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Compounded Tirzepatide

Where the FDA rules now stand, the documented safety signal, prescriber liability, and how to answer a patient who arrives with a compounded vial.

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Practice, Billing & Coverage

Billing & Coding 2026

Obesity ICD-10 codes, CPT and HCPCS for weight-loss programs, documentation that survives review, and the fixes for the common denials.

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Prior Authorization Playbook

Why PAs get denied, the documentation payers are actually looking for, step therapy, and how to run appeals without burning staff hours.

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Build a Medical Weight-Loss Program

Choosing a business model, setting clinical protocols, staffing to scope of practice, compliance, and pricing a program that sustains itself.

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GLP-1 Certification Training · CWMP™

Prescribing GLP-1s well
is a trainable clinical skill.

Semaglutide and tirzepatide changed what patients expect from their providers. IAPAM’s GLP-1 certification gives you the protocols, titration schedules, monitoring parameters and side-effect management to run a medically supervised weight management program with confidence.

What the certification covers

Semaglutide & tirzepatide protocolsPrescribing & dosing
Titration & patient monitoringIncluding side effects
Clean Start Weight Loss® programPractice-in-a-box
CWMP™ certificationBoth formats
AMA PRA Category 1 CMEs6 online · 9 in person

For MD/DO, NP, APRN, PA, RN and other licensed providers

Two formats. Same credential.

Online — self-paced
6 CMEs · 7–10 hours · 24/7 access

In person — Scottsdale, AZ
9 CMEs · 1-day intensive · body contouring included

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Questions? Call 1-866-211-6901

Related

Starting a Medical Weight Management Practice

The business-side companion hub: program setup, regulations, marketing, telehealth, staffing and vendor resources for launching a clinic.

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Medical Weight Management Library

Patient-facing explainers on GLP-1 medications — useful to hand to patients, and to see what they have already read before their visit.

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GLP-1 Certification Training

The CME-accredited certification behind this library — protocols, titration, monitoring and side-effect management, online or in person.

See the training →

Disclaimer: The guides in this library are for informational and educational purposes for licensed healthcare providers and do not constitute medical or prescribing advice. Dosing, labeling and regulatory status in this drug class change frequently; always verify the current FDA-approved prescribing information for the specific product before prescribing.

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