Celebrating 20 Years of Training in Botox®, Aesthetic Medicine
and Medical Weight Management

Start Training Now
IAPAM Logo
Register Now
Days
Hours
Minutes

Save 25% on Hands-on Botox® Training

All 2026 dates on sale. Register before December 31!

Celebrating 20 Years of Excellence in Botox®, Aesthetic Medicine & Medical Weight Management Training & Certification

IAPAM Logo

Save 25% off all 2026 Botox Training Dates!

Sale ends in:

Days
Hours
Minutes
Sign Up & Get 25% Off!

Home » Medical Weight Management Library  »Does Ozempic® Need to Be Refrigerated?

Does Ozempic® Need to Be Refrigerated?

Ozempic® (semaglutide) is a medication prescribed to manage type 2 diabetes and aid in weight loss. Proper storage of Ozempic® is crucial to maintain its efficacy and safety. The medication comes in pre-filled pens, and it is important to store it correctly, especially before its first use.

Ozempic Refrigerated

What Happens If Ozempic® Is Not Refrigerated Before First Use

According to the manufacturer’s instructions, Ozempic® should be refrigerated between 36°F and 46°F (2°C and 8°C) before its initial use. Failure to refrigerate the medication within this temperature range may result in reduced effectiveness and potential harm to the user.

Ozempic® Storage After Opening

Once you have started using Ozempic®, the storage requirements change. After initial use, the pre-filled pens can be kept at a temperature not exceeding 86°F (30°C) for up to 56 days. This means you can store the pen at room temperature, but it’s crucial to avoid extreme heat and direct sunlight, as they can affect the medication’s stability.

Be sure to keep track of the date when you first opened the pen to ensure you discard it after the 56-day period, even if there is still some medication remaining.

Learn to Start a Profitable Aesthetics Practice in Just 4-Days!

February 13-16 (only 5 spots left!)
in sunny Scottsdale, AZ

Make More. Work Less.

Start your transitioning to aesthetic medicine and learn everything you need to grow a profitable aesthetics practice in just 4-days! 

February 13-16
Only 5 spots left!
Scottsdale, AZ

Starting at $2,995
Save up to $3,605 when you register for all 4-days!
Register Now

*Prices advertised are preferred member pricing. Membership is $295/yr and can be added during the registration process to access the discounted pricing. 

I Forgot to Refrigerate My Ozempic®

If you accidentally left your Ozempic® pen out of the refrigerator before the first use, do not panic. Take the following steps to determine its usability:

Check the temperature: If the room temperature did not exceed 86°F (30°C) and the pen was out of the refrigerator for a short time, it should be safe to use.

Inspect the solution: Before injecting, examine the Ozempic® solution in the pen. If it appears discolored, cloudy, or contains particles, do not use it, as this indicates possible degradation.

Consult your healthcare provider: If you have any doubts or concerns, seek advice from your doctor or pharmacist before using the medication.

Can I Inject Ozempic® Cold?

While it is not recommended to inject Ozempic® while it is extremely cold, you can let the pen sit at room temperature for around 30 minutes before use to ensure it’s not uncomfortably cold. Avoid heating the pen or using warm water to speed up the warming process, as this can damage the medication.

Always follow the instructions provided by your healthcare provider and the medication’s packaging to ensure the proper storage and usage of Ozempic®. When in doubt, seek professional advice to ensure your safety and the medication’s effectiveness in managing your condition.

The Fastest Way to Increase Your Knowledge of GLP-1s for Weight Loss

On-Demand Training with the IAPAM Learning Lab

Sign up today and expand your knowledge & skills in Botox®, Fillers, Lasers,
Chemical Peels, Microdermabrasion and PRP for Aesthetics!

Start Training Now

Conclusion

As noted earlier, Ozempic® (semaglutide) is a medication used for the treatment of type 2 diabetes and weight management. It belongs to the class of GLP-1 receptor agonists and works by increasing insulin production while reducing glucagon secretion, resulting in improved blood sugar control. Ozempic® has been shown to be effective in lowering blood glucose levels, promoting weight loss, and reducing the risk of cardiovascular events in patients with diabetes.

However, like any medication, it is essential to use Ozempic® as directed by a healthcare professional. Proper storage and handling, especially refrigeration before first use, are crucial to maintain its efficacy and safety. Adhering to the prescribed dosage and following any specific instructions provided by the healthcare provider will help maximize the benefits of Ozempic® while minimizing the risk of potential side effects.


Disclaimer: The information provided here is for general knowledge only and should not be considered medical advice. For any questions or concerns about your health or medications, please consult your physician or healthcare provider. They are best equipped to provide guidance specific to your medical needs.

Ready to Offer GLP-1 Weight Loss in Your Practice?

Get certified and start building independent revenue streams—not corporate contracts.
  • Own Your Patient Relationships

Build an independent practice with direct patient relationships—not through corporate intermediaries.

  • Immediate Revenue Generation

Start offering GLP-1 services the day after training. Practices see $100K–$900K in additional annual revenue.

  • Stay Current with Protocols

Renewable certification keeps you compliant with evolving FDA guidelines and latest treatment protocols.

  • Complete Business Training

Learn marketing, patient flow optimization, and practice-building strategies—not just clinical skills.

Join thousands of healthcare providers who’ve added profitable GLP-1 weight loss services to their practice. Choose from online, self-study certification or join us live in sunny Scottsdale, Arizona for our 1-day training session.

Start Training Now

Ready to Transform Your Practice with GLP-1s?

Request your Quick Start Checklist for Starting or Integrating a New GLP-1 for Weight Loss Guide.

Request your free copy