Xeomin® vs Botox® vs Dysport® Explained
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Executive Summary Xeomin® vs Botox® vs Dysport®
- The main difference between Xeomin and Botox or Dysport, is that Xeomin contains just one ingredient: botulinum toxin A.
- The manufacturing process is slightly different with all 3, which leads to some potential, subtle differences in clinical practice.
- Xeomin is a “naked injectable,” meaning that it does not contain any additives. A benefit of a pure-form injectable is that the human body is less likely to become resistant to it. Some patients have developed antibodies to Botox and Dysport.
- Xeomin is the only one of the three (Xeomin, Botox and Dysport) injectables that does not need to be refrigerated before use, due to its lack of additives.
- The cost of Xeomin is roughly the same as for Botox at $5.00-5.40 per unit. Dysport is about $3.99 per unit.
- Patients average 20 units of Xeomin per visit, vs. 20 units of Botox and 40 units of Dysport.
- The average retail cost to a patient in the US, for a Xeomin treatment, is between $300.00 – $400.00 every 3 months based on the recommended dose of 20 Units per treatment session.
- Xeomin might have the slowest “onset” of action of the 3 (Dysport onset in 24 hours, Botox onset in 72 hours, and Xeomin onset in 4 days.)
- Xeomin may be “mildly more convenient” than Botox or Dysport, as the “product’s lack of complex proteins will help prevent antibody formation, or resistance to neuromuscular treatment with botulinum type A toxin, in patients being treated for neuromuscular conditions.”
- Neurotoxins diffuse differently, in part because Botox and Dysport have protective proteins clustered around the active part of the molecule, while Xeomin has no protective proteins.
- Botox has a full complement of protective proteins and weighs about 900 kD. Dysport is a mixture of 500 kD and 300 kD complexes of protective proteins and botulinum toxin A. Being heavier, these complexes migrate more slowly than Xeomin/NT-201, which is BTX-A without protective proteins. Conversely, you will have less precision.
- Dysport has been shown to “drift” or diffuse more than Botox, increasing the chances of an accidental droopy eyelid or unintentional relaxation of a neighboring muscle due to diffusion of the product.
- Botox and Dysport are not interchangeable because the products are dosed and injected differently.
For a complete overview on Xeomin: Instructions for Preparation, Dosage and Administration, please visit https://iapam.com/xeomin-incobotulinumtoxina
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Explaining Xeomin® vs. Botox®
There are a number of similarities between Xeomin® and Botox®. These are listed below –
1. Both Xeomin® and Botox® consist of the same basic ingredient – Botulinum toxin A, a toxin that this produced by the Clostridium botulinum bacteria. This neurotoxin acts by blocking the neuromuscular junction and has an effect on the skin and muscles it is injected into.
2. Both Xeomin® and Botox® exert their effect in around 7 days after it has been injected, with the effects lasting up to 6 months. The overall effect that results from Xeomin® and Botox® are the same.
3. Both Xeomin® and Botox® are measured in the same units, making it easy for the treating physician to measure up the required dose.
4. The cost of Xeomin® and Botox® are comparable, making the administration of either drug a choice that can lie with the physician or the patient.
There are only a few differences between Xeomin® and Botox®. These have been listed below:
1. The basic structure of Xeomin® and Botox® are different, even though the toxin is the same. Botox is encased within a protein structure, while Xeomin lacks this protein covering and is, in fact, the ‘naked’ botulinum toxin. This protein casing on Botox can cause immune reactions that can eventually block the actions on botulinum toxin when injected. It is believed that this is an advantage that Xeomin bears over Botox as it results in no antibody formation with repeated injections of Xeomin.
2. Botox® is stored in a freezer or at temperatures between 2 to 8°C. It, therefore, requires it to be transported in a freezer. On the other hand, Xeomin® does not necessarily need to be stored in a freezer or refrigerator, making transporting the product a lot easier and even cheaper.
3. Xeomin® is manufactured by Merz Pharma while Botox® is manufactured by Allergan.
In most cases, Xeomin® can be offered if patients develop antibodies to Botox®.
Please note: Botox, Allergan Botox Cosmetic and Juvederm are registered trademarks of Allergan, Inc. Dysport, Restylane and Perlane are registered trademarks of Galderma. Xeomin is a registered trademark of Merz Pharmaceuticals, LLC.
DISCLOSURE OF UNLABELED USE
This document contains a discussion of agents that are not indicated by the U.S. Food and Drug Administration. The International Association for Physicians in Aesthetic Medicine (IAPAM), Allergan, Inc., and Medicis, Inc., do not recommend the use of any agent outside of the labeled indications. The opinions expressed in this document are those of the contributors and do not necessarily represent the views of the IAPAM, Allergan, Inc. or Medicis, Inc. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
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